| Isaac Okoro Rankings 2020-2021 | Stats Glossary  |
| Games with 10 or more Efficiency Recap | Cleveland Cavaliers Record : 14 - 18 | Isaac Okoro |
| No | Date | Game | Res | Score | Efficiency Recap |
| 1 | May 14 | at Washington | L | 105-120 | 14 |
| 2 | May 12 | vs Boston | W | 102-94 | 18 |
| 3 | May 10 | vs Indiana | L | 102-111 | 23 |
| 4 | May 7 | at Dallas | L | 90-110 | 15 |
| 5 | May 4 | vs Phoenix | L | 118-134 | 35 |
| 6 | May 1 | vs Miami | L | 107-124 | 10 |
| 7 | Apr 28 | vs Orlando | L | 104-109 | 18 |
| 8 | Apr 26 | at Toronto | L | 96-112 | 16 |
| 9 | Apr 17 | at Chicago | L | 96-106 | 14 |
| 10 | Apr 14 | at Charlotte | W | 103-90 | 12 |
| 11 | Apr 11 | vs New_Orleans | L | 109-116 | 22 |
| 12 | Apr 8 | at Oklahoma_City | W | 129-102 | 11 |
| 13 | Apr 5 | at San_Antonio | W | 125-101 | 12 |
| 14 | Apr 3 | at Miami | L | 101-115 | 16 |
| 15 | Apr 1 | vs Philadelphia | L | 94-114 | 13 |
| 16 | Mar 24 | at Chicago | W | 103-94 | 17 |
| 17 | Mar 21 | vs Toronto | W | 116-105 | 14 |
| 18 | Mar 17 | vs Boston | W | 117-110 | 15 |
| 19 | Mar 16 | at Miami | L | 98-113 | 12 |
| 20 | Feb 27 | at Philadelphia | W | 112-109 | 25 |
| 21 | Feb 24 | vs Houston | W | 112-96 | 10 |
| 22 | Feb 23 | vs Atlanta | W | 112-111 | 15 |
| 23 | Feb 21 | vs Oklahoma_City | L | 101-117 | 12 |
| 24 | Feb 19 | vs Denver | L | 103-120 | 10 |
| 25 | Feb 5 | vs Milwaukee | L | 105-123 | 11 |
| 26 | Jan 31 | at Minnesota | L | 104-109 | 15 |
| 27 | Jan 27 | vs Detroit | W | 122-107 | 17 |
| 28 | Jan 25 | vs L.A.Lakers | L | 108-115 | 10 |
| 29 | Jan 22 | vs Brooklyn | W | 125-113 | 10 |
| 30 | Jan 15 | vs New_York | W | 106-103 | 17 |
| 31 | Jan 6 | at Orlando | L | 94-105 | 11 |
| 32 | Dec 23 | vs Charlotte | W | 121-114 | 16 |
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